Role of ticagrelor in clopidogrel nonresponders: resistance is futile?
نویسندگان
چکیده
Dual antiplatelet therapy with aspirin and a thienopyridine drug that blocks the platelet adenosine diphosphate receptor P2Y12 is the cornerstone of management in patients presenting with acute coronary syndrome (ACS). Clopidogrel is the most widely used thienopyridine, with evidence of benefit in non–ST-elevation myocardial infarction (MI),1 percutaneous coronary intervention (PCI),2 and ST-elevation MI treated with thrombolysis or primary PCI.3,4
منابع مشابه
Response to ticagrelor in clopidogrel nonresponders and responders and effect of switching therapies: the RESPOND study.
BACKGROUND The antiplatelet effects of the Platelet Inhibition and Patient Outcomes (PLATO) trial dose of ticagrelor in patients nonresponsive to clopidogrel and after they switch agents are unknown. METHODS AND RESULTS Patients with stable coronary artery disease on aspirin therapy received a 300-mg clopidogrel load; nonresponders were identified by light transmittance aggregometry. In a 2-w...
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Stent thrombosis is a dreaded complication of percutaneous coronary interventions (PCI). It is a prominent cause of mortality and major bleeding [1]. Antiplatelet therapy has played an important role in mitigating this adverse event, yet it is still a major complication. Clopidogrel, an irreversible P2Y12 inhibitor has been a mainstay of antiplatelet therapy for years. Clopidogrel’s nature as a...
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ورودعنوان ژورنال:
- Circulation
دوره 121 10 شماره
صفحات -
تاریخ انتشار 2010